What are Alpha 2 Macroglobulin Injections?

Alpha 2 macroglobulin, also known as A2M injection therapy, is a regenerative medicine technique frequently used to treat osteoarthritis, but is showing promise in many other applications as well.

Regenerative medicine encourages the body’s natural healing properties to overcome local areas of injury or disease, pain, or slow healing.

A2M is specifically used to promote tissue growth, prevent the breakdown of cartilage, and support the overall restoration of an affected joint.

A2M is one of the largest plasma proteins found in the blood, and it binds with specific damage-causing proteins. When the body has an injured joint, the A2M naturally occurring in the body may not present itself in a high enough concentration to accelerate healing. However, when injected in higher concentration into the damaged joint, it has been shown to target the destructive enzymes.

Where Does A2M Come From?

Similar to Platelet Rich Plasma Therapy (PRP), a small sample of your blood is drawn (similar to a lab test sample) and placed in a centrifuge that spins the blood at high speeds, separating the platelets from the other components. The process is handled manually by a lab technician, producing a concentrated volume of A2M.

What Results Can I Expect?

Unlike PRP or prolotherapy, which purposefully induce an inflammatory response to increase healing, A2M is a non-inflammatory procedure because of the role of the protease inhibitors. A2M slows the progression of arthritis by improving the joint environment.

While most regenerative procedures result in temporary discomfort to the patient because of an expected inflammation following the injection, A2M patients rarely exhibit any significant pain following their procedures, other than the mild discomfort that comes from needles perforating tissue.

If you are suffering from chronic pain and would like to learn more about PRP and A2M, call us today at 818-325-2088 for a consultation with a pain specialist at CSPP.